Adrian Isaacs is Professor of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology and a founding investigator of the UK Dementia Research Institute. His research examines the genetic and molecular mechanisms that cause ALS and frontotemporal dementia (FTD), with a particular focus on the C9orf72 gene, mutations in which are the most common genetic cause of both ALS and FTD. He has made a significant contribution to understanding how the C9orf72 mutation causes neurodegeneration. His lab uses a range of experimental systems including fruit fly, mouse and iPSC-neuron models of ALS/FTD combined with biomarker development, high-throughput screening and gene therapy methodologies to identity new therapeutic approaches.