Dr Jeffrey Illif
University of Washington School of Medicine, USA
Trained in vascular physiology and neuroscience, Jeffrey Iliff was part of the research team at the University of Rochester Medical Center that discovered the ‘glymphatic’ system, the brain’s cleaning system that is active during sleep. The Arthur J. and Marcella McCaffray Endowed Professor in Alzheimer’s Disease and a Professor of Psychiatry and Behavioral Science at the University of Washington, Iliff’s recent studies have shown that the glymphatic system fails in the aging brain and in the young brain after traumatic brain injury. These latter studies suggest that ongoing impairment of the brain’s waste removal system after brain trauma may be the basis for the link between brain trauma (such as concussion) early in life and the development of dementia in the decades that follow.
Research in his lab focuses on identifying the molecular changes that underlie glymphatic system failure with aging and after trauma, extending these experimental studies into human subjects and clinical populations with an aim of developing new treatment and prevention strategies for neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
"Glymphatic system dysfunction as a driver of protein mis-aggregation in neurodegenerative disease"